![]() The TNF- level in normal animals was found to be 21.0 3.5 pg/ml. The increased tumor necrosis factor (TNF)- level in tumor control (802.6 12.0) was significantly (P < 0.01) decreased to 175.2 16.5 after S. The serum glutathione and -glutamyl transpeptidase (GGT) levels were found to be significantly decreased compared with tumor-bearing control animals. muricatum treatment could not only stimulate the immune system but also significantly (P < 0.01) inhibit the growth of transplantable tumor. P values less than 0.05 were considered statistically significant. Statistical analyses were performed using a one-way analysis of variance (ANOVA) followed by Dunnetts test using GraphPad Instat software. Statistical Analysis: The results were expressed as mean (SD). ![]() The anti-inflammatory activity of the fruit extract was evaluated using carrageenan and formaldehyde models. The anti-tumor activity of the fruit extract was studied against Daltons lymphoma ascites (DLA) cell line induced solid and ascites tumor models. muricatum fruits was evaluated by assessing the relative organ weight, bone marrow cellularity, -esterase activity, and by studying the phagocytic activity by carbon clearance test. Materials and Methods: Immunomodulatory activity of S. ![]() muricatum fruits in experimental mice models. ![]() Aim: The objective of present study is to explore the immunomodulatory, anticancer, and anti-inflammatory activities of the methanol extract of S. Traditionally, the fruits are used in the treatment of diabetes and cancer. (Solanaceae) is commonly known as melon pear and sweet cucumber grown in South America, New Zealand, and India. Context: The pepino fruit Solanum muricatum Ait.
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